An inhibitor of Bcl-2 family proteins (Kis = is = 550 and 354 nM, respectively), cytotoxic in a panel of SCLC, leukemia, and lymphoma cell lines (mean EC50 = 1 µM), induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC50 = 0.08 µM), induces tumor regression in NCI H146 SCLC and RS4,11 ALL mouse xenograft models at 100 mg/kg
